![]() He no longer carries his uncertainties about the surface and has gained two close friends - Alberto and Giulia. īy the end of the movie, Luca is much braver and wiser than the fearful, nervous version of him that existed early in the story. He credits Alberto with teaching him how to be crazy. Alberto is able to teach Luca to ignore his doubts and leave his comfort zone, which is how he gained his skills on a bicycle that he needed to compete in the Portorosso Cup. After Alberto introduces him to the surface, Luca attempts to confidently refuse staying there as he believes himself to be a “good kid.” When he receives the opportunity to approach the surface shortly later on, his first reaction is reluctance to disobey his parents’ orders and see Alberto again.Īs the movie progresses, Luca is able to expand on his curiosities about human life and what was on the surface as Alberto shows him his collection of human items. He meets Alberto, who Luca thinks is a human diver, but turns out to be like a sea-monster just like him. He is afraid of the surface, but is also very curious about it. In the beginning of the film, Luca starts out as a very timid and shy character. Before he obtained his new outfit, he was seen wearing green shorts, presumably made of seaweed or kelp. He also seems to have a blue dorsal fin, located on his back. He has a long tail that goes to a whip-thin-end with blue caudal fins on his tail, forearms, and calves. His eyes are a redder shade of brown with oval shaped pupils and yellow scleras. In Luca's sea-monster form, he has green scales and blue fin-like appendages that are assumed to be the sea-monster equivalent of hair. He wears an ivory flannel shirt with aqua striped patterning, dark blue shorts and is barefoot all the time. ![]() He also has chocolate brown hair and round brown eyes. In Luca's human form, he is a slender, short, fair-skinned boy, with rosy cheeks and freckles. His central job in the family was to herd the goatfish and keep them out of the reaches of fishing boats. He had little knowledge of the surface besides his wonderings of what existed on it, and had never thought to question his parents’ orders to stay away from it. VERA correctly labelled 70% of the botanicals, indicating the most similar substances and the main features associated with carcinogenicity.Luca is a 12-year-old boy who was raised underwater alongside his parents, Daniela and Lorenzo, and his grandmother, Grandma Paguro. To test the VERA software, carcinogenicity was selected as the endpoint of interest for a range of botanicals. Carcinogenicity is a complex endpoint with several mechanisms, requiring resource intensive experimental bioassays and a large number of animals as such, the use of read-across as part of new approach methodologies would support carcinogenicity assessment. The software finds the most similar compounds with a certain feature, e.g., structural alerts and molecular groups, and provides clusters of similar substances while comparing these similar substances within different clusters. VERA provides a means to assess similarity between chemicals using structural alerts specific to the property, pre-defined molecular groups and structural similarity. The present study aims to screen and assess the effect of the key components in a molecule which may escape the evaluation for read-across based only on the most similar substance(s) using a new open-access software: Virtual Extensive Read-Across (VERA). However, differences between the target and the source substances exist. ![]() ![]() Read-across applies the principle of similarity to identify the most similar substances to represent a given target substance in data-poor situations. ![]()
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